They dont show a difference... they show that humanity is completely dependent on the natural world.
BNW- Humans in the BNW need to take surragates to surpress their human side because they cant function properly in a world with nothing natural (John proves that)
BR- Replicants are the only people to show any humanity. This is what makes them dangerous because they are "more human than human". Without the natural worlds humans have lost their humanity
